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目的:通过测定高温作业人群热休克蛋白70抗体(HSP70-Ab)水平,探讨HSP70-Ab与高温对职业人员心血管损伤程度的关系及其在心血管病发病机制中的作用。方法:采用蛋白质免疫印迹-酶联免疫吸附测定法(Western blot-ELISA)分别检测高温作业人员(实验组,62例)、行政后勤服务人员(对照组,43例)血浆中HSP70-Ab抗体滴度。结果:高温组HSP70-Ab阳性率明显高于对照组,差异有统计学意义(P<0.05)。结论:HSP70可能与高温作业人员心血管病的发病率有关,血浆HSP70-Ab可能是接触有害职业因素相关心血管病的生物学标志。
OBJECTIVE: To investigate the relationship between the HSP70-Ab level and the severity of cardiovascular injury and its role in the pathogenesis of cardiovascular disease by measuring the level of heat shock protein 70 (HSP70-Ab) in workers at high temperature. Methods: Western blot-ELISA was used to detect the levels of HSP70-Ab antibody in plasma (experimental group, 62 patients) and administrative logisticians (control group, 43 patients) degree. Results: The positive rate of HSP70-Ab in high temperature group was significantly higher than that in control group (P <0.05). Conclusion: HSP70 may be related to the incidence of cardiovascular diseases in high temperature workers. Plasma HSP70-Ab may be the biological marker of cardiovascular diseases related to occupational exposure to harmful occupational factors.