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目的 :探讨铱 192间质放疗 ,不同剂量分割对实验性鼠脑胶质瘤的影响。方法 :选用种植胶质瘤 17只 SD鼠进行 0～ 10 0 0 c Gy/ 2次 /天的分割剂量放疗 ,比较 15 0～ 30 0 c Gy组和 5 0 0～ 10 0 0 c Gy组放疗过程中的影像变化 ,模式特征和生存期。结果 :5 0 0～ 10 0 0 c Gy组瘤体出现中央坏死率为 10 0 % (4 / 4) ,15 0～ 30 0 c Gy组为 2 2 .2 % (2 / 9) ,两组相比 P<0 .0 5。治疗中瘤体中央无坏死组 (n=7)的体积平均缩小率为 76 .4% ,瘤体中央有坏死组 (n=6 )缩小率为 2 .3% (P<0 .0 1) ,放疗结束二者分别为 80 .1%和 37.8% ,有显著性差异 (P<0 .0 5 )。放疗死亡鼠的平均生存期为 2 7天 (n=8) ,高于对照组鼠平均生存 7天 (n=3) ,P<0 .0 5。放疗结束 1个月 15 0～ 30 0 c Gy组的生存率为 80 %(8/ 10 ) ,5 0 0～ 10 0 0 c Gy组全部死亡 ,P<0 .0 1。结论 :15 0～ 30 0 c Gy组肿瘤以体积缩小为主 ,5 0 0～ 10 0 0 c Gy组以中央坏死为主 ,前者体积缩小更明显 ,生存期延长
Objective: To investigate the effect of iridium 192 interstitial radiotherapy and different doses on the experimental rat glioma. Methods: Seventeen SD rats with glioma were treated with split dose of 0 ~ 100 c Gy / 2 times / day. Radiotherapy was compared between 15 0 ~ 30 0 c Gy group and 5 0 0 ~ 10 0 0 c Gy group Changes in the process of the image, pattern characteristics and survival. Results: The central necrosis rate was 100% (4/4) in the group of 50 Gy to 100 Gy and 22.2% (2/9) in the group of 150 to 30 0 c Gy Compared to P <0. 05. The average volume reduction rate was 76.4% in the non-necrotic group (n = 7) and 2.0% (n = 6) in the central necrosis group (n = 6) , And the end of radiotherapy were 80.1% and 37.8%, respectively, with significant difference (P <0.05). The mean survival time of rats irradiated by radiotherapy was 27 days (n = 8), which was higher than that of the control rats (7 days) (n = 3), P <0.05. One month after the end of radiotherapy, the survival rate of c Gy group was 80% (8/10) between 15 0 and 30 0, and all the patients were between 0 0 and 10 0 0 c Gy group, P <0.01. Conclusions: The tumors in 15 0 ~ 30 0 c Gy group were mainly reduced in size, while the central necrosis was mainly in the group of 0 0 ~ 100 0 c Gy. The former had a smaller size and the longer the survival period