本文首先介绍了膦酰肽的分类、结构特征以及膦酰肽的主要合成方法,然后详细介绍了类Mannich反应在合成氨基膦酸衍生物中的应用,并介绍了以类Mannich反应为关键步骤通过汇聚式的方法合成膦酰肽、膦酰酯肽、次膦酰肽、次膦酰酯肽、磺酰膦酰杂交肽的研究进展.汇聚式的合成方法具有原料简单、合成步骤少、原子经济性好等优点. In this paper, the classification, structural characteristics and the main synthesis methods of phosphonopeptides were introduced firstly. Then the applications of Mannich-like reactions in the synthesis of aminophosphonic acid derivatives were introduced in detail. The class Mannich reaction as the key step was introduced The research progress on the synthesis of phosphonopeptide, phosphono-peptide, phosphinyl-peptide, phosphinyl-ester peptide and sulfonylphosphonic acid hybrid peptide by the convergent method is as follows: The convergent synthesis method has the advantages of simple raw materials, less synthetic steps, Sex is good and so on.