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目的探讨银杏叶片联合阿魏酸钠治疗短暂性脑缺血发作的临床疗效。方法选取2015年3月—2016年3月在日照市人民医院接受治疗的短暂性脑缺血发作患者78例,按照治疗方法的不同分为对照组和治疗组,每组各39例。对照组静脉滴注注射用阿魏酸钠,0.3 g加入5%葡萄糖注射液250 m L,1次/d。治疗组在对照治疗基础上口服银杏叶片,2片/次,3次/d。两组均连续治疗2周。观察两组的临床疗效,同时比较两组治疗前后血浆黏度(CP)、血细胞比容(HCT)、血小板聚集率(PAR)、纤维蛋白原(FIB)、内皮素-1(ET-1)、基质金属蛋白酶-9(MMP-9)、血管紧张素-II(Ang-II)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为84.62%、92.31%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者CP、HCT、PAR、FIB、ET-1、MMP-9、Ang-II均较同组治疗前显著降低,同组治疗前后差异均有统计学意义(P<0.05),且治疗组这些观察指标的降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论银杏叶片联合阿魏酸钠治疗短暂性脑缺血发作具有较好的临床疗效,可明显改善患者血液流变学指标,降低血清ET-1、MMP-9、Ang-II水平,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of ginkgo leaf combined with sodium ferulate in the treatment of transient ischemic attack. Methods Totally 78 patients with transient ischemic attack who were treated in Rizhao People’s Hospital from March 2015 to March 2016 were divided into control group and treatment group with 39 cases in each group according to different treatment methods. Control group, intravenous sodium ferulate injection, 0.3 g 5% glucose injection 250 m L, 1 / d. The treatment group on the basis of the control treatment oral ginkgo leaf, 2 tablets / time, 3 times / d. Two groups were treated for 2 weeks. The clinical effects of the two groups were observed. The changes of plasma viscosity (CP), hematocrit (HCT), platelet aggregation rate (PAR), fibrinogen (FIB), endothelin- Matrix metalloproteinase-9 (MMP-9), angiotensin-II (Ang-II) changes. Results After treatment, the total effective rates of the control group and the treatment group were 84.62% and 92.31% respectively, with significant difference between the two groups (P <0.05). After treatment, the CP, HCT, PAR, FIB, ET-1, MMP-9 and Ang-II in the two groups were significantly lower than those before treatment in the two groups, with statistical significance (P <0.05) The reduction of these indexes in the treatment group was better than that in the control group, and the differences between the two groups were statistically significant (P <0.05). Conclusion Ginkgo biloba combined with sodium ferulate in the treatment of transient ischemic attack has better clinical curative effect, can significantly improve the patient’s hemorheology index, lower serum ET-1, MMP-9, Ang-II levels, with a certain Clinical application value.