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目的了解氟喹诺酮类抗菌药物在临床治疗中发生不良反应的情况,为临床合理使用该类抗茵药物提供依据。方法采用回顾性调查方法,对我院2000年12月至2005年12月收集的氟喹诺酮类抗茵药物所致的不良反应报表进行统计分析。结果氟喹诺酮类药物诱发的不良反应175例,涉及6种氟喹诺酮类药物及身体各个部分,最常见的为皮肤及附件损害,在常规治疗剂量下,用药2～7d患者出现ADRs的症状占总ADRs的54·9%。结论应关注氟喹诺酮类抗菌药物的不良反应,提高合理用药水平。
Objective To understand the adverse reactions of fluoroquinolone antibacterials in clinical treatment and provide basis for clinical rational use of such anti-inflammatory drugs. Methods A retrospective survey was conducted to analyze the adverse reaction reports of fluoroquinolone antimicrobial drugs collected in our hospital from December 2000 to December 2005. Results Fluoroquinolones induced adverse reactions in 175 cases, involving six fluoroquinolones and various parts of the body, the most common skin and accessories damage, at conventional therapeutic doses, medication 2 ~ 7d patients with ADRs symptoms accounted for the total 54.9% of ADRs. Conclusion Fluoroquinolone antibacterial drugs should be concerned about the adverse reactions and improve the rational use of drugs.