近20年,随着免疫力低下人群的增加和广谱抗菌药物的广泛使用,侵袭性真菌感染(Invasive fun-gal infection,IFI)已日益普遍。IFI的发病率和病死率居高不下,其诊断和治疗极具挑战性,本文就IFI诊断和治疗新进展综述如下。1IFI非培养诊断进展由于IFI早期症状和体征常缺乏特异性,故 In the recent 20 years, Invasive fungal infection (IFI) has become increasingly common with the increase of immunocompromised people and the widespread use of broad-spectrum antimicrobial agents. IFI morbidity and mortality high, its diagnosis and treatment is very challenging, this article on the IFI diagnosis and treatment of new progress are summarized below. 1IFI non-cultured diagnosis of progress due to IFI early symptoms and signs often lack specificity, so