谷氨酸不仅是人和哺乳动物中枢神经系统的基本兴奋性神经递质,也参与外周感觉系统的突触传递。然而,过量谷氨酸引起的谷氨酸受体过度激活导致谷氨酸兴奋性神经毒性。本文对谷氨酸在前庭终器的神经传递和谷氨酸在晕动病中对其的兴奋毒性进行了讨论,并对与谷氨酸神经传递过程相关的抗晕动病药物进行综述。 Glutamate is not only the basic excitatory neurotransmitter of the central nervous system of humans and mammals, but also participates in the synaptic transmission of the peripheral sensory system. However, excessive glutamate-induced glutamate receptor over-activation leads to glutamate-excitotoxicity. In this paper, the neurotransmitter of glutamate in vestibular cements and the excitotoxicity of glutamic acid in motion sickness were discussed, and the anti-motion sickness drugs related to glutamate neurotransmission were reviewed.