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53例(62只眼)难治性青光眼患者,随机分成丝裂霉素(mitomycin C.简写 MMC)组与对照组。行小梁切除术时,MMC 组于术中将0.4mg/ml 的 MMC 棉片置于手术区结膜瓣下及板层巩膜瓣下5分钟,再用生理盐水冲洗。术后平均随访10个月,结果表明:MMC 组功能性滤过泡为95,5%,对照组为56.5%;MMC 组90.9%的眼不用任何药物眼压≤2.8kPa,对照组为47.8%;MMC组术后眼压为1.87±0.58kPa,对照组为2.71±0.87kPa;上述结果进行统计学分析,P<0.01。MMC 组术后持续性低眼压者占9.1%,其中一眼发生低眼压性黄斑病变。本文提示,MMC 作为青光眼滤过性手术的辅助药物,能够显著延长滤过泡功能,降低眼压,提高手术成功率,但使用时要注意适应证的选择。
Fifty-three patients (62 eyes) with refractory glaucoma were randomly divided into mitomycin C (MMC) group and control group. During trabeculectomy, the MMC group received 0.4 mg / ml MMC cotton tissue under the conjunctiva flap and lamellar scleral flap for 5 minutes during operation, and then rinsed with saline. After a mean follow-up of 10 months, the results showed that the functional filtration bleb in MMC group was 95.5% and 56.5% in control group, and 90.9% in MMC group without any intraocular pressure≤2.8kPa and in control group was 47.8% ; The intraocular pressure was 1.87 ± 0.58kPa in the MMC group and 2.71 ± 0.87kPa in the control group; The above results were statistically analyzed (P <0.01). MMC group postoperative persistent low intraocular pressure accounted for 9.1%, one of the occurrence of low pressure ocular macular degeneration. This article suggests that MMC as a glaucoma filtration surgery auxiliary drugs, can significantly extend the filtration bleb function, reduce intraocular pressure and improve the success rate of surgery, but the use of indications should pay attention to the choice.