论文部分内容阅读
普瑞巴林是一种新型γ-氨基丁酸(GABA)受体激动剂,能阻断电压依赖性钙通道,减少神经递质的释放,临床主要用于治疗外周神经痛以及辅助性治疗局限性部分癫痫发作。本文对普瑞巴林药理作用、药动学及临床研究评价进行综述。
Pregabalin is a novel gamma-aminobutyric acid (GABA) receptor agonist that blocks voltage-dependent calcium channels and reduces the release of neurotransmitters. It is mainly used in the treatment of peripheral neuralgia and its limitations in adjuvant therapy Partial seizures. This article reviews the pharmacological effects, pharmacokinetics and clinical evaluation of pregabalin.