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目的研究宫颈上皮内瘤变(CIN)患者支原体感染情况及耐药分析,为临床诊治提供依据。方法采用回顾性方法对523例宫颈上皮内瘤变(CIN)患者的分泌物进行解脲支原体(Uu)和人型支原体(Mh)培养及药敏试验。结果 523例宫颈上皮内瘤变患者Uu的检出率为55.25%(289例),Uu和Mh混合感染的检出率为13.58%(71例),检出5例单一Mh感染的患者。对抗菌药物敏感率高的是强力霉素(91.16%)、美满霉素(90.48%),其次是交沙霉素(81.29%)、克拉霉素(75.85%),对氧氟沙星的敏感率最低,仅为10.20%。结论宫颈上皮内瘤变患者中支原体感染存在普遍,应合理使用抗菌药物治疗,支原体感染与宫颈上皮内瘤变的发生可能密切相关。
Objective To study the mycoplasma infection and drug resistance in patients with cervical intraepithelial neoplasia (CIN), and to provide the basis for clinical diagnosis and treatment. Methods 523 cases of cervical intraepithelial neoplasia (CIN) were treated with Uu and Mh culture and drug susceptibility test by retrospective method. Results The positive rate of Uu in 523 cases of cervical intraepithelial neoplasia was 55.25% (289 cases). The detection rate of mixed Uu and Mh was 13.58% (71 cases), and 5 cases of single Mh infection were detected. Doxycycline (91.16%) and minocycline (90.48%) were sensitive to antimicrobial agents, followed by jasmomycin (81.29%), clarithromycin (75.85%), sensitive to ofloxacin The lowest rate, only 10.20%. Conclusions Mycoplasma infection is common in patients with cervical intraepithelial neoplasia. Antibiotic therapy should be used reasonably. Mycoplasma infection may be closely related to the occurrence of cervical intraepithelial neoplasia.