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目的探讨局部晚期宫颈癌新辅助化疗近期临床疗效。方法 2010年1月—2014年12月收治的局部晚期宫颈癌患者200例,随机分为两组,手术组患者直接行手术治疗,干预组患者先行新辅助化疗再行手术治疗,对比临床缓解率、肿瘤直径、术中出血量、膀胱功能恢复时间、术后转移率和宫旁浸润率。结果干预组和手术组临床缓解率分别为83.00%和63.00%,比较差异有统计学意义(P<0.05)。干预组肿瘤直径、术中出血量、膀胱功能恢复时间明显短于手术组,比较差异有统计学意义(P<0.05)。干预组术后转移率和宫旁浸润率明显少于手术组,比较差异有统计学意义(P<0.05)。结论局部晚期宫颈癌患者先行新辅助化疗再行手术治疗,可有效提高缓解率,缩小肿瘤体积,为手术创造条件,减少术后并发症和复发率,值得临床推广应用。
Objective To investigate the recent clinical efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer. Methods From January 2010 to December 2014, 200 cases of locally advanced cervical cancer were randomly divided into two groups. The patients in the operation group were treated by surgery directly. The patients in the intervention group were treated with neoadjuvant chemotherapy before surgery. The clinical response rate , Tumor diameter, intraoperative blood loss, bladder function recovery time, postoperative metastasis rate and uterine infiltration rate. Results The clinical remission rates in intervention group and operation group were 83.00% and 63.00%, respectively, with statistical significance (P <0.05). Intervention group tumor diameter, blood loss, bladder function recovery time was significantly shorter than the surgical group, the difference was statistically significant (P <0.05). The rate of postoperative metastasis and paravaginal invasion in the intervention group was significantly less than that in the operation group, with significant difference (P <0.05). Conclusions Neoadjuvant chemotherapy in locally advanced cervical cancer patients can be surgically treated by neoadjuvant chemotherapy, which can effectively improve the remission rate, reduce the tumor volume, create conditions for surgery and reduce the postoperative complications and recurrence rate, which is worthy of clinical application.