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以胶原酶诱发大鼠急性脑出血，结果其血浆内皮素（ＥＴ）、血浆肌酸激酶（ＣＫ）及血浆血管性假血友病因子（ｖＷＦ）水平均较正常对照组有显著升高（Ｐ＜０．０５）。中药醒脑健神胶囊组及清开灵注射液组ＥＴ水平与模型组比较均有下降，但Ｐ＞０．０５；醒脑健神胶囊组的ＣＫ水平较模型组有非常显著的降低（Ｐ＜０．０１），接近正常对照组水平，而清开灵组ＣＫ水平虽亦有降低，但Ｐ＞０．０５；给中药醒脑健神胶囊合清开灵注射液８ｄ的中药组血浆ｖＷＦ水平较同期以水代替中药处理的模型组有所降低（Ｐ＜０．０５）。
With collagenase induced acute cerebral hemorrhage in rats, plasma endothelin (ET), plasma creatine kinase (CK), and plasma von Willebrand factor (vWF) levels were significantly higher than those in normal controls (P). <0.05). Compared with the model group, the levels of ET in the Chinese Medicine Xingnaojianshen Capsule Group and Qingkailing Injection Group decreased, but P>0.05; the CK level of Xingnaojianshen Capsule Group was significantly lower than that of the model group (P <0.01), close to the normal control group, while the CK level in the Qing Kai Ling group also decreased, but P> 0.05; to the Chinese medicine Xingnao Jianshen capsule and Qing Kailing injection 8 days of Chinese medicine group plasma vWF Compared with the same period, the model group treated with water instead of traditional Chinese medicine was lower (P<0.05).