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目的研究血管紧张素转换酶(angiotensin converting enzyme,ACE)基因多态性与高血压脑梗死之间的相关关系及可能机制。方法对52例高血压脑梗死和70例健康对照者用聚合酶链反应(polymerase chain reaction,PCR)技术和琼脂糖凝胶电泳法分别进行ACE基因插入/缺失(Insertion/Deletion,I/D)多态性测定。分析比较高血压脑梗死组与对照组之间ACE基因多态性的分布差异。结果高血压脑梗死组DD基因型和D等位基因频率分别为32.7%、53.8%,与对照组比较明显增高,且差异有统计学意义(P<0.05)。结论ACE基因多态性与合并高血压的脑梗死有关,可增加高血压脑梗死的发病危险。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and hypertensive cerebral infarction and its possible mechanism. Methods Fifty - two patients with hypertensive cerebral infarction and 70 healthy controls were enrolled in this study. The ACE gene insertion / deletion (I / D) was performed by polymerase chain reaction (PCR) and agarose gel electrophoresis respectively. Polymorphism determination. Analysis and comparison of ACE gene polymorphism distribution between hypertensive cerebral infarction group and control group. Results The frequencies of DD genotype and D allele in hypertensive cerebral infarction group were 32.7% and 53.8%, respectively, which were significantly higher than those in control group (P <0.05). Conclusion The ACE gene polymorphism is associated with cerebral infarction complicated by hypertension, which may increase the risk of developing cerebral infarction.