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作者以前瞻性方法在动物体上逐一比较了经导管射频能量消蚀(RFA)与直流电消蚀(DCA)产生的血流动力学、电生理和组织学改变。把18只狗分成两组(各9只)。把6F4电极导管从股动脉插入左室作消蚀用。从对侧股动脉把猪尾巴导管插入左室作压力描记和心室造影。射频能量(750KHZ)由电手术器产生,直流电由常规除颤器产生。分别对6只狗各以100、200、300J 的能量分别在左室前壁和后壁两个部位进行1次消蚀。经DCA的狗中,左室收缩压从121.3±24.5降至94.2±18.7mmHg(P<0.01),并有室壁运动异常。DCA后,左室射血分数即刻从50±2%降至34±3%(P<0.01),但4周后升至43±3%。在RFA组,左室收缩压、室壁运动和射血分数均没有明显变化。经DCA后,所有狗均即刻出现持续的(≥
The authors prospectively compared the hemodynamic, electrophysiological and histological changes produced by radio-frequency catheter ablation (RFA) and direct current ablation (DCA) on animals. Eighteen dogs were divided into two groups (nine each). 6F4 lead from the femoral artery into the left ventricular for ablation. The pig tail catheter was inserted into the left ventricle for compression and ventriculography from the contralateral femoral artery. RF energy (750 KHz) is generated by the electrosurgical unit, which is generated by a conventional defibrillator. 6 dogs were 100,200,300 J energy respectively in the left anterior wall and posterior wall of the two parts of an eclipse. Left ventricular systolic pressure decreased from 121.3 ± 24.5 to 94.2 ± 18.7 mmHg (P <0.01) in DCA-challenged dogs and had abnormal wall motion. After DCA, LVEF decreased immediately from 50 ± 2% to 34 ± 3% (P <0.01), but rose to 43 ± 3% after 4 weeks. In RFA group, LV systolic pressure, wall motion and ejection fraction did not change significantly. After DCA, all dogs appeared immediately (≥