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目的探讨新生儿HIE及新生大鼠缺氧后βEP变化方法本文应用RIA法测定35例不同程度的HIE患儿急性期、恢复期血浆、脑脊液中βEp含量,与20例健康新生儿比较并用7日龄Wistar大鼠制成HIE模型,取病变侧脑匀浆后测βEp含量,干湿重法测脑含水率。结果HIE患儿血浆和脑脊液中βEp显著高于对照组,且病情愈重,βEp增高愈明显。缺氧缺血性新生大鼠脑组织βEp含量与含水率均明显高于对照组,且脑组织βEp含量与含水率显著正相关。结论βEp参与了HIE病理生理过程。
Objective To investigate neonatal hypoxic HIE Hypoxia and β EP changes in the method of RIA method to determine the 35 cases of children with HIE at different levels of acute and convalescent plasma and cerebrospinal fluid β Ep content and 20 healthy newborns The 7-day-old Wistar rats were compared and made into HIE model, βEp content was measured after lesion lateral brain homogenate, and the brain water content was measured by wet-dry method. Results HIE children plasma and cerebrospinal fluid β Ep was significantly higher than the control group, and the more serious the disease, β Ep increased more significantly. Hypoxic-ischemic neonatal rat brain β-Ep content and water content were significantly higher than the control group, and β-Ep content in brain tissue and water content was significantly positively correlated. Conclusion β-Ep involved in HIE pathophysiological process.