目的探讨新生儿ＨＩＥ及新生大鼠缺氧后βＥＰ变化方法本文应用ＲＩＡ法测定３５例不同程度的ＨＩＥ患儿急性期、恢复期血浆、脑脊液中βＥｐ含量，与２０例健康新生儿比较并用７日龄Ｗｉｓｔａｒ大鼠制成ＨＩＥ模型，取病变侧脑匀浆后测βＥｐ含量，干湿重法测脑含水率。结果ＨＩＥ患儿血浆和脑脊液中βＥｐ显著高于对照组，且病情愈重，βＥｐ增高愈明显。缺氧缺血性新生大鼠脑组织βＥｐ含量与含水率均明显高于对照组，且脑组织βＥｐ含量与含水率显著正相关。结论βＥｐ参与了ＨＩＥ病理生理过程。 Objective To investigate neonatal hypoxic HIE Hypoxia and β  EP changes in the method of RIA method to determine the 35 cases of children with HIE at different levels of acute and convalescent plasma and cerebrospinal fluid β  Ep content and 20 healthy newborns The 7-day-old Wistar rats were compared and made into HIE model, βEp content was measured after lesion lateral brain homogenate, and the brain water content was measured by wet-dry method. Results HIE children plasma and cerebrospinal fluid β  Ep was significantly higher than the control group, and the more serious the disease, β  Ep increased more significantly. Hypoxic-ischemic neonatal rat brain β-Ep content and water content were significantly higher than the control group, and β-Ep content in brain tissue and water content was significantly positively correlated. Conclusion β-Ep involved in HIE pathophysiological process.