论文部分内容阅读
利用受体理论阐明生命现象的生理和病理过程,解释药物的药理作用机制、药物分子结构和效应的关系,已成为药理研究的关键性技术。 受体(receptor)指能特异性地识别和结合配基并通过相应的信号转导机制,以产生最终生物效应的分子。这些受体主要是细胞膜或细胞内的大分子化合物,如蛋白质、核酸、脂质等,。随着分子生物学等技术的应用,近年来对不少受体的基因、分子结构、受体激动后信息转导的分子过程有了更深入的了解。 乙酰胆碱(acetylcholiine.Ach)是胆碱能神经系统的递
The use of receptor theory to elucidate the physiological and pathological processes of life phenomena, explain the pharmacological mechanism of drugs, the relationship between drug molecule structure and effect has become a key technology in pharmacological research. Receptors refer to molecules that specifically recognize and bind ligands and pass the appropriate signal transduction mechanisms to produce the ultimate biological effect. These receptors are mainly macrophages, such as proteins, nucleic acids, lipids, etc., in the cell membrane or cells. With the application of molecular biology and other technologies, in recent years, many receptors have a more in-depth understanding of the molecular, molecular structure and molecular process of signal transduction after receptor activation. Acetylcholine (acetylcholiine.Ach) is the cholinergic system of the delivery