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本研究探讨早期霍奇金淋巴瘤(HL)综合治疗模式与扩大野放疗模式的疗效。回顾性分析解放军307医院1987年1月至2010年12月确诊的104例早期HL患者临床资料,分为综合治疗组76例与扩大野放疗组28例,比较两种治疗模式对疗效、生存状况及不良反应的影响。结果表明,104例早期HL患者中位生存85.42个月,综合治疗组与扩大野放疗组的完全缓解率(72.4%vs 71.4%,P=0.924)、总有效率(97.4%vs 96.4%,P=0.779)、5年总生存率(OS,89.5%vs 89.1%,P=0.528)和8年OS(81.3%vs 70.6%,P=0.528)无统计学差异,但两组的5年无进展生存率(PFS,84.2%vs 69.0%,P=0.040)、8年PFS(80.0%vs 55.5%,P=0.040)和5年复发率(28.1%vs 45.6%,P=0.023)有差异。结论:早期HL的综合治疗模式较扩大野放疗模式可提高PFS及降低复发率,但两组OS未见差异。
This study explored the combined treatment of early Hodgkin’s lymphoma (HL) and the efficacy of extended field radiation therapy. The clinical data of 104 patients with early-stage HL diagnosed from January 1987 to December 2010 in People’s Liberation Army 307 Hospital were retrospectively analyzed. There were 76 patients in the comprehensive treatment group and 28 patients in the extended field radiotherapy group. The efficacy and survival status of the two treatment modalities were compared And adverse effects. The results showed that the median survival time of 104 patients with early HL was 85.42 months. The complete response rate (97.4% vs 96.4%, P = 0.924) in the combination therapy group and the extended radiotherapy group (72.4% vs 71.4%, P = 0.779). There was no significant difference in 5-year overall survival (OS, 89.5% vs 89.1%, P = 0.528) and 8-year OS (81.3% vs 70.6%, P = 0.528) There were differences in survival rate (PFS 84.2% vs 69.0%, P = 0.040), 8-year PFS (80.0% vs 55.5%, P = 0.040) and 5-year relapse rate (28.1% vs 45.6%, P = 0.023). Conclusion: Compared with the extended radiotherapy mode, the comprehensive treatment of early HL can increase the PFS and reduce the recurrence rate, but there is no difference between the two groups.