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目的 探讨乳腺典型髓样癌、非典型髓样癌形态相似而预后差异显著的分子机理。方法 采用免疫组织化学 (s p)法测定 18例乳腺典型髓样癌、30例非典型髓样癌中E cadherin、CD4 4v6的表达。 结果 E cadherin蛋白的表达强度 ,典型髓样癌高于非典型髓样癌 (P <0 .0 5 ) ;非典型髓样癌中CD4 4v6的表达强度明显高于典型髓样癌 (P <0 .0 5 )。结论 E cadherin、CD4 4v6表达的显著差异是乳腺典型髓样癌、非典型髓样癌形态相似而预后迥异的重要原因之一
Objective To investigate the molecular mechanism of the typical prognosis difference between typical medullary carcinoma of breast and atypical medullary carcinoma. Methods Immunohistochemistry (s p) was used to detect the expression of E cadherin and CD4 4v6 in 18 cases of typical medullary carcinoma of breast and 30 cases of atypical medullary carcinoma. Results The expression of E cadherin protein was higher in typical medullary carcinoma than that in atypical medullary carcinoma (P <0.05). The expression of CD4 4v6 in atypical medullary carcinoma was significantly higher than that in typical medullary carcinoma (P <0.05) .0 5). Conclusions The significant difference of E cadherin and CD4 4v6 expression is one of the important reasons for the similar pattern of breast cancer atypical medullary carcinoma and different prognosis