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[目的]探讨口腔鳞状细胞癌(OSCC)样本中MMP-3和αvβ6的表达情况及其临床意义。[方法]对80例临床诊断为口腔鱗状细胞癌患者的样本进行免疫组化和免疫荧光共定位检测MMP-3和αvβ6的表达。应用Fisher确切概率法评价临床病理参数与MMP-3和αvβ6的表达水平的关系。应用Speamian相关分析验证MMP-3和αvβ6之间的相关性。Kaplan-Meier曲线和Log-rank检测生存分析。[结果]与不典型增生组织相比,MMP-3和αvβ6在口腔鳞状细胞癌呈强表达,特别是在肿瘤侵袭的边缘。MMP-3阴性表达组(79.59%)和αvβ6阴性表达组(88.15%)的5年生存率明显优于MMP-3阳性表达组(31.45%)和αvβ6阳性表达组(42.82%),且MMP-3和αvβ6表达之间存在相关性(r=0.5983)。[结论]MMP-3、αvβ6表达增加与口腔鳞状細胞癌不利的临床预后因素和生存率的降低相关。
[Objective] To investigate the expression of MMP-3 and αvβ6 in oral squamous cell carcinoma (OSCC) specimens and their clinical significance. [Method] The expression of MMP-3 and αvβ6 in 80 specimens of patients with oral squamous cell carcinoma were detected by immunohistochemistry and immunofluorescence staining. Fisher exact test was used to assess the relationship between clinicopathological parameters and the expression of MMP-3 and αvβ6. Speamian correlation analysis was used to verify the correlation between MMP-3 and αvβ6. Kaplan-Meier curves and Log-rank test for survival analysis. [Results] Compared with atypical hyperplasia, MMP-3 and αvβ6 were strongly expressed in oral squamous cell carcinoma, especially at the edge of tumor invasion. The 5-year survival rate of MMP-3 negative expression group (79.59%) and αvβ6 negative expression group (88.15%) was significantly higher than that of MMP-3 positive expression group (31.45%) and αvβ6 positive expression group (42.82% There was a correlation between 3 and αvβ6 expression (r = 0.5983). [Conclusion] The increased expression of MMP-3 and αvβ6 is associated with the adverse prognostic factors of oral squamous cell carcinoma and the decrease of survival rate.