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Macrophage migration inhibitory factor (MIF), the first lymphokine to be reported,has been rediscovered as an irnmunomodulator and hormone as well as a proinflammatory cytokine. The neuropeptide α-melanocyte-stimulating hormone (α-MSH) is a neuroimmunomodulator that modulates the actions and the production of proinflammatory cytokines in experimental inflammation by actions on melanocortin receptors. We investigated the effects of α-MSH on MIF mRNA expression in CNS, adrenal, and spleen of rats witfi endotoxemia using RTPCR and Northern blot.The results indicated that α-MSH (250 ng), given intravenously (iv) with LPS challenge, inhibited the
Macrophage migration inhibitory factor (MIF), the first lymphokine to be reported, has been rediscovered as an irnmunomodulator and hormone as well as a proinflammatory cytokine. The neuropeptide α-melanocyte-stimulating hormone (α-MSH) is a neuroimmunomodulator that modulates the actions and the production of proinflammatory cytokines in experimental inflammation by actions on melanocortin receptors. We investigated the effects of α-MSH on MIF mRNA expression in CNS, adrenal, and spleen of rats witfi endotoxemia using RTPCR and Northern blot. These results indicate that α- MSH (250 ng), given intravenously (iv) with LPS challenge, inhibited the