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阿司匹林(ASP)不可逆地抑制血小板环氧化酶,在男性 ASP 半衰期短(20分钟),但摄入 ASP后至少间隔48小时,血小板不聚集或不能合成前列腺素(PG)。为了阐明 ASP 抑制巨核细胞环氧化酶的合成,是否是该种活性延迟的原因,作者特研究了人体巨核细胞血栓烷(TX)B_2的生成。从6例至少10天内来服药治疗的志愿者抽取髂骨骨髓。每例获取12份骨髓标本,每份3ml,共36ml。例1、2的骨髓作对照,例3、4在抽取标本前4小时服用乙酰水杨酸钙600mg、(相当于 ASP500mg)。
Aspirin (ASP) irreversibly inhibits platelet cyclooxygenase, has a short half-life (20 minutes) in men, but does not aggregate or synthesize prostaglandins (PG) at least 48 hours after the ASP is taken. To clarify whether ASP inhibition of megakaryocyte cyclooxygenase synthesis is responsible for this delayed activity, we investigated the generation of thromboxane B 2 in human megakaryocytes. Iliac bone marrow was drawn from 6 volunteers who took the medication for at least 10 days. Each sample obtained 12 bone marrow samples, each 3ml, a total of 36ml. The bone marrow of cases 1 and 2 served as a control, and cases 3 and 4 took 600 mg of acetylsalicylic acid calcium (equivalent to 500 mg of ASP) 4 hours before taking the specimen.