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目的:探讨丁苯酞软胶囊联合奥扎格雷钠在短暂性脑缺血发作(TIA)病情治疗中的临床效果。方法:选取住院确诊为TIA患者60例,随机分为用药组和对照组,每组30例,对照组使用奥扎格雷钠治疗,用药组使用丁苯酞软胶囊和奥扎格雷钠联合治疗。观察两组的临床疗效。结果:用药组的终止发作时间短于对照组(P<0.05)。治疗后纤维蛋白原含量和甘油三酯含量与治疗前相比较,两种的变化差异均有统计学意义(P<0.05),但两组治疗后纤维蛋白原含量和甘油三酯含量的分布上差异均有统计学意义(P<0.05),用药组的治疗效果要明显优于对照组。两组3个月、6个月及9个月TIA复发率及卒中发生率差异有统计学意义(P<0.05)。结论:丁苯酞软胶囊与奥扎格雷钠联用治疗TIA安全有效,复发率及脑卒中的发生率低,值得临床广泛应用。
Objective: To investigate the clinical effect of butylphthalide soft capsule combined with ozagrel sodium in the treatment of transient ischemic attack (TIA). Methods: Sixty hospitalized patients with TIA were selected and randomly divided into medication group and control group, with 30 cases in each group. The control group was treated with ozagrel sodium. The combination group was treated with butylphthalide soft capsule and ozagrel sodium. The clinical efficacy of the two groups was observed. Results: The termination of the treatment group was shorter than the control group (P <0.05). After treatment, fibrinogen content and triglyceride content compared with before treatment, the difference between the two were statistically significant (P <0.05), but the two groups after treatment fibrinogen content and distribution of triglyceride content The differences were statistically significant (P <0.05), the treatment group was significantly better than the control group. There was significant difference in TIA recurrence rate and stroke incidence between the two groups at 3 months, 6 months and 9 months (P <0.05). Conclusion: Butylphthalide soft capsules combined with ozagrel sodium in the treatment of TIA safe and effective, the recurrence rate and the incidence of stroke is low, it is widely used in clinical.