胆固醇肉芽肿首于1917年由Manassé氏所描述,但直到Birrell(1956)等氏重新提出注意这一特殊病变之前,本病向被人们所忽略,甚至有经验的病理学家也常将它与上皮样胆脂瘤相混淆。本文介绍经临床和组织学确诊为胆固醇肉芽肿的电子显微镜所见,特别介绍其超微结构和巨细胞的作用。 Cholesterol granuloma was first described by Manassé in 1917, but until Birrell (1956) et al. Revisited this particular lesion, the disease was neglected and even experienced pathologists often associated it with Epithelial cholesteatoma confused. This article describes clinical and histological diagnosis of cholesterol granuloma seen by electron microscopy, in particular its ultrastructure and the role of giant cells.