众所周知,在产生炎症反应和免疫反应的部位能看到白细胞浸润,其细胞种类因致炎刺激的种类不同而异。已证明,引起这种现象是因为在局部产生的化学趋化因子(chemotactic factor, CF)的种类不同。白细胞介助于自身细胞膜上的受体,所感受的CF浓度梯度,向浓度高方向趋化,而最早看到的白细胞是中性粒细胞。最近又发现,一种中性粒细胞的新的CF是白细胞介素-8(IL-8)。该因子是由LPS(脂多糖)、IL-1(白细胞介素-1)和TNF(肿瘤坏死因子)刺激单核细胞而产生的一种中性粒细胞趋化因子。开始时 It is well-known that leukocyte infiltration can be seen at the site of inflammatory reaction and immune response, and the cell type varies with the type of inflammatory stimuli. It has been shown that this phenomenon is caused by the different types of chemotactic factors (CFs) produced locally. Leukocytes, which mediate receptors on their own membranes, experience a gradient of CF concentrations that chemotaxis toward high concentrations, whereas the earliest seen leukocytes were neutrophils. Recently, it has also been found that a neutrophil’s new CF is interleukin-8 (IL-8). This factor is a neutrophil chemokine produced by stimulation of monocytes with LPS (lipopolysaccharide), IL-1 (interleukin-1) and TNF (tumor necrosis factor). starting time