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目的:分析我院抗茵药不良反应/事件(ADR/ADE)报告,了解我院抗菌药ADR/ADE发生的特点,为临床合理用药提供参考。方法:对我院2006年1月~2012年12月收集到的324例抗菌药ADR/ADE报告,从患者情况、不良反应的临床表现、给药途径、抗茵药的种类及因果关系的评价等方面进行回顾性统计分析。结果:324例抗菌药不良反应/事件报告中,女性多于男性;50~87岁的患者所占比例最高;头孢菌素类居首位(47.53%);其次为喹诺酮类(29.01%);给药途径以静滴所占比例最高(90.12%);累及的系统及器官前三位是皮肤及其附件、消化系统、中枢神经系统。结论:加强抗茵药分级管理,严格掌握用药指征,减少或者避免不良反应/事件的发生。
OBJECTIVE: To analyze ADR / ADE reports in our hospital to understand the characteristics of antimicrobial ADR / ADE in our hospital and to provide reference for clinical rational drug use. Methods: A total of 324 cases of ADR / ADE were collected from January 2006 to December 2012 in our hospital from the aspects of the patients, the clinical manifestations of the adverse reactions, the route of administration, the types of anti-inflammatory drugs and causality And other aspects of retrospective statistical analysis. Results: There were more women than men in the adverse reactions / incidents reports of 324 antibacterials. The highest proportion of patients aged 50-87 years were cephalosporins (47.53%), followed by quinolones (29.01%), The route of administration was the highest (90.12%) with intravenous infusion; the top three systems and organs involved were skin and its appendages, digestive system and central nervous system. Conclusion: To strengthen the classification of anti-drug management, strict control of indications to reduce or avoid the occurrence of adverse reactions / events.