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目的:分析左氧氟沙星药物不良反应(ADR)发生的特点,促进临床合理用药。方法:收集2004年5月—2008年12月间122例左氧氟沙星药物不良反应报告,分别从患者性别、年龄、既往ADR史、给药途径、临床表现、处理方法及结果等方面进行分析。结果:122例ADR中既往有药物ADR史的17.21%(21/122),通过静脉给药的97.54%(119/122),用药过程中出现ADR的78.69%(96/122)。ADR主要临床表现以皮肤及附件、消化系统损害最常见,所有病例均治愈或好转。结论:应用左氧氟沙星时应重视患者ADR的既往史,并尽量采用口服给药,静脉给药时宜加强监护。
Objective: To analyze the characteristics of levofloxacin adverse drug reactions (ADRs) and to promote the rational use of drugs. Methods: A total of 122 levofloxacin adverse drug reactions (ADRs) were collected from May 2004 to December 2008, and their gender, age, previous ADR history, route of administration, clinical manifestations, treatment methods and results were analyzed. Results: The past ADR history of ADR in 122 cases was 17.21% (21/122), 97.54% (119/122) in intravenous administration and 78.69% (96/122) in ADR. ADR main clinical manifestations of the skin and accessories, the most common digestive system damage, all cases were cured or improved. Conclusion: Levofloxacin should pay attention to the past history of patients with ADR, and try to use oral administration, intravenous administration should be strengthened care.