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[目的]观察怀山药多糖对胃溃疡大鼠的治疗作用,研究怀山药多糖对胃溃疡大鼠胃组织碱性成纤维细胞生长因子(bFGF)水平的影响。[方法]将50只大鼠随机分为5组,分别为空白组、模型组、怀山药多糖组、替普瑞酮组和怀山药多糖+替普瑞酮组。观察并比较各组胃溃疡的愈合情况,取胃组织匀浆检测并比较bFGF水平。[结果]怀山药多糖组的溃疡指数显著低于模型组(P<0.01);怀山药多糖组的胃组织bFGF水平显著高于空白组(P<0.01)和模型组(P<0.05)。[结论]怀山药多糖具有良好的胃黏膜保护作用,其机制可能与上调胃溃疡大鼠胃组织bFGF水平有关。
[Objective] To observe the therapeutic effect of yam yam polysaccharide on gastric ulcer in rats and study the effect of yam yam polysaccharide on the level of bFGF in gastric ulcer rats. [Method] 50 rats were randomly divided into 5 groups, namely blank group, model group, Huayama polysaccharide group, Teprenone group and Huayama polysaccharide + Teprenone group. The healing of gastric ulcer in each group was observed and compared. The level of bFGF in gastric homogenate was detected and compared. [Results] The ulcer index of Huayuankang polysaccharide group was significantly lower than that of model group (P <0.01). The bFGF level of Huayama polysaccharide group was significantly higher than that of blank group (P <0.01) and model group (P <0.05). [Conclusion] The polysaccharide from Huashan medicinal has a good protective effect on gastric mucosa. The mechanism may be related to the up-regulation of bFGF in stomach tissue of gastric ulcer rats.