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已知,促黄体生成素释放激素(LHRH)刺激垂体促性腺激素的合成及释放,继而引致性腺激素的变化。近年报告长期给大鼠用LHRH或其高活性类似物导致性腺重量减轻及性激素生成减少,这一抑制作用推测是由于大鼠性腺对促性腺激素的敏感性降低。本文观察到给正常妇女连续使用LHRH使垂体和性腺的敏感性降低。作者选择了3例26～30岁的正常妇女作为受试者,在卵泡期早期开始静脉点滴LHRH,每分钟1.4μg,连续用药72小时。每4小时采一次血样,低温保存待测定激素。其中1例连续进行第二次实验,在36小时中每6小时肌注50IU的人垂体FSH。
It is known that luteinizing hormone releasing hormone (LHRH) stimulates the synthesis and release of pituitary gonadotropin, which in turn leads to changes in gonadal hormones. In recent years, it has been reported that long-term administration of LHRH or its highly active analogue to rats results in a decrease in gonad weight and decrease in sex hormone production, presumably due to reduced gonadal sensitivity to gonadotrophin in the rat gonads. This article observes that the continuous use of LHRH to normal women reduces the sensitivity of the pituitary and gonads. The authors selected 3 normal women aged 26 to 30 years as subjects who started intravenous LHRH at the follicular phase at 1.4 μg per minute for 72 hours. Blood samples were taken every 4 hours and the hormone to be tested was stored at low temperature. One of the patients underwent the second experiment continuously, with 50 IU of human pituitary FSH intramuscularly every 6 hours for 36 hours.