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尼卡地平(硝苯苄胺啶,Nicardipine,Perdipine,YC—93)是二氢吡啶类新型钙通道阻滞剂。治疗脑循环障碍、冠心病、高血压病均有显著疗效。此药的血管扩张作用主要是由于抑制钙离子向血管平滑肌流入,cAMP磷酸二脂酶的抑制,招致细胞内cAMP增多,并与促进钙向肌肉内质网摄入有一定关系。该药直接作用于血管平滑肌,使血管扩张,选择性作用于脑动脉和冠状动脉,增加脑及冠脉的血流量,有良好的降压疗效,并有降低心肌耗氧量,减轻左室后负荷及增加心输出量等作用。
Nicardipine (nifedipine, Nicardipine, Perdipine, YC-93) is a novel dihydropyridine calcium channel blocker. Treatment of cerebral circulation disorders, coronary heart disease, hypertension have a significant effect. The vasodilator effect of this drug is mainly due to inhibition of calcium influx into vascular smooth muscle, cAMP phosphodiesterase inhibition, resulting in intracellular cAMP increased, and with the promotion of calcium to the muscle endoplasmic reticulum uptake of a certain relationship. The drug directly on the vascular smooth muscle, the blood vessels to dilate, selectively acting on the cerebral arteries and coronary arteries, increasing blood flow to the brain and coronary artery, a good antihypertensive effect, and reduce myocardial oxygen consumption, reduce left ventricular Load and increase cardiac output and so on.