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清华大学医学院常智杰教授课题组和上海交通大学医学院健康科学研究所秦樾研究员课题组经过深入研究,发现了肿瘤发生中磷酸酶底物特异性调控新机制。相关研究论文发表在《分子细胞》上。此前,对于信号转导与转录激活因子3(STAT3)信号通路的调控,一直是肿瘤领域研究的热点。STAT3在多种肿瘤中都处于持续磷酸化激活的状态。而对激活的STAT3起直接负调控作用的是酪氨酸磷酸酶。与一般酶具有高度的底物特异性不同,酪氨酸磷酸酶的特异性比较差,同一种
Prof. Zhi-Jie Chang from Tsinghua University School of Medicine and Prof. QIN Zhi from Shanghai Jiao Tong University School of Medicine, Institute of Health Sciences, after a series of in-depth studies, discovered a new mechanism for the specific regulation of phosphatase substrates in tumorigenesis. Related research papers published in “molecular cells.” Previously, the regulation of signal transducer and activator of transcription 3 (STAT3) signaling pathway has been a hot topic in the field of oncology. STAT3 is in a state of sustained phosphorylation activation in a variety of tumors. A direct negative regulator of activated STAT3 is tyrosine phosphatase. With the general enzyme has a high degree of substrate specificity, tyrosine phosphatase specificity is poor, the same