论文部分内容阅读
目的:探讨复方中药四泰片对胰岛素抵抗综合征(insulinresistancesyn-drome,IRS)大鼠、血压、血脂、血糖、胰岛素的影响。方法:选用清洁级雄性SD大鼠40只,按随机区组设计分为正常对照组、模型组、四泰片组、卡托普利组4组。采用高糖高脂饲料喂养大鼠8周,造成IRS大鼠模型,观察四泰片对IRS大鼠血压、血糖、血脂、胰岛素水平及胰岛素敏感性指数(insulinsensitivityindex,ISI)的影响。结果:治疗后四泰片组、卡托普利组大鼠收缩压犤(128±4),(110±2)mmHg,(1mmHg=0.133kPa)犦与治疗前犤(158±8),(157±7)mmHg犦和模型组犤(165±6)mmHg犦比较,差异具有显著性意义(t=11.86～28.99,P<0.01)。四泰片组大鼠总胆固醇、三酰甘油均较模型组下降(t=44.27,9.14,P<0.01),高密度脂蛋白胆固醇(highdensitylipoproteincholesterol,HDL-C)升高(t=703,P<0.01)。模型组大鼠空腹胰岛素(fastinginsulin,FINS)均升高,ISI下降,与正常对照组比较,差异均有显著性意义(t=7.14,9.35,P<0.01),胰岛素抵抗明显,造模成功;四泰片组、卡托普利组大鼠空腹血糖、FINS均下降,与模型组比较,差异均有显著性意义(t=11.95,6.71,P<0.01),卡托普利组空腹血糖与四泰片组比较,差异有显著性意义(t=8.33,P<0.01);四泰片组、卡托普利组ISI均升高,与模型组比?
OBJECTIVE: To investigate the effect of Sitai Tablets on insulin resistance syndrome (IRS) rats, blood pressure, blood lipids, blood glucose and insulin. METHODS: Forty male clean SD rats were randomly divided into normal control group, model group, Sitai tablet group and captopril group. The rats were fed with high-sugar and high-fat diet for 8 weeks to induce IRS rat model. The effects of Sitai Tablet on blood pressure, blood glucose, blood lipid, insulin level and insulin sensitivity index (ISI) of IRS rats were observed. RESULTS: After treatment, the systolic pressure 犤(128±4), (110±2) mmHg, (1mmHg=0.133kPa) and the pretreatment hemorrhoids (158±8) in the Sitai Tablet group and the captopril group, ( The difference between 157±7 mmHg and model group 犤(165±6)mmHg犦 was significant (t=11.86～28.99, P<0.01). The total cholesterol and triacylglycerol in the Sitai Tablet group were lower than those in the model group (t=44.27, 9.14, P<0.01), and the high density lipoprotein cholesterol (HDL-C) was elevated (t=703, P< 0.01). Fasting insulin (FINS) in the model group increased, ISI decreased, compared with the normal control group, the difference was significant (t = 7.14, 9.35, P <0.01), insulin resistance was obvious, and the model was successful; Fasting blood glucose and FINS decreased in the Sitai Tablet group and captopril group, and there was a significant difference between the four groups (t=11.95, 6.71, P<0.01) and the model group. Fasting blood glucose in the captopril group There was a significant difference in the Sitai Tablet group (t=8.33, P<0.01). The ISI in the Sitai Tablet group and the captopril group was higher than that in the model group.