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近几年,国内外着眼于靶向微泡造影剂的研究,利用超声波与微泡造影剂的相互作用及所产生的生物学效应,可实现微泡所携带的基因/药物等向目标组织的转移释放,介导肿瘤细胞的凋亡及肿瘤微血管的栓塞阻断等,从而起到靶向治疗的作用。随着各种兼具诊断治疗双重作用的超声探头和靶向微泡造影剂包括纳米级微泡造影剂的研制,以及对超声生物学效应的深入研究,超声微泡介导肿瘤靶向治疗将为临床肿瘤的治疗带来新的希望。
In recent years, at home and abroad focus on targeting microbubble contrast agent research, the use of ultrasound and microbubble contrast agent interaction and the biological effects produced by microbubbles can be carried by genes / drugs to the target tissue Transfer and release, mediate the apoptosis of tumor cells and embolization of tumor microvessels, which play a role in targeted therapy. With the development of various ultrasound probes and targeted microbubble contrast agents, including nanoscale microbubble contrast agents, as well as in-depth studies of the biological effects of ultrasound, ultrasound microbubble-mediated tumor targeting therapy will Bring new hope for the treatment of clinical tumor.