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目的 :探讨 2型糖尿病 (2型 DM)以及合并糖尿病肾病 (DN)患者血清胰岛素样生长因子 1(IGF- 1)的变化。方法 :应用免疫放射分析法检测血清 IGF- 1水平 ,采用酸乙醇提取法去除 IGF结合蛋白 (IGFBP)的影响。结果 :1年龄、性别匹配的 DN组 (79例 )、非 DN组 (79例 )和健康对照组 (5 0例 )间 FBG存在显著性差异 (F =31.1,P =0 .0 0 0 1) ,该 3组 FBG分别为(7.81± 2 .5 7) mm ol/ L,(7.2 2± 1.87) mm ol/ L,(5 .0 6± 0 .4 8) mm ol/ L;2该 3组间 Hb A1c存在显著性差异 (F =2 2 .33,P =0 .0 0 0 1) ,3组 Hb A1c分别为 (8.91± 2 .86 ) % ,(8.96± 3.2 4 ) % ,(5 .99± 1.0 8) % ;33组间 IGF- 1存在显著性差异 (F =9.15 ,P =0 .0 0 0 2 ) ,3组 IGF- 1分别为 (185 .4 9± 12 0 .89) μg/ L,(132 .6 4± 6 2 .0 3) μg/ L,(132 .35± 4 5 .16 ) μg/ L。结论 :2型DM的非 DN患者血清 IGF- 1水平与正常人群无显著性差异 ,DN患者血清 IGF- 1水平明显高于非 DN患者 ,提示 IGF- 1可能是 2型 DM肾病发病因素之一。
Objective: To investigate the changes of serum insulin-like growth factor 1 (IGF-1) in type 2 diabetes mellitus (DM) and patients with diabetic nephropathy (DN). Methods: The level of serum IGF-1 was detected by immuno-radioactive assay and the effect of IGFBP was removed by acid-ethanol extraction. RESULTS: There was a significant difference in FBG between 1-year-old DN group (79 cases), non-DN group (79 cases) and healthy control group (50 cases) (F = 31.1, P = 0.0001 ), The FBG of the three groups were (7.81 ± 2.57) mm ol / L, (7.22 ± 1.87) mm ol / L, (5.06 ± 0.48) mm ol / L, respectively; There were significant differences in Hb A1c between the three groups (F = 2.33, P = 0.00001). The Hb A1c in the three groups were (8.91 ± 2.86)%, (8.96 ± 3.24)%, (5 .99 ± 1.08)%. There was a significant difference in IGF-1 between the three groups (F = 9.15, P = 0.00002) .89) μg / L, (132.6 ± 0.623) μg / L, (132.35 ± 4.55) μg / L. Conclusion: Serum IGF-1 levels in non-DN patients with type 2 diabetes mellitus were not significantly different from those in normal people. Serum IGF-1 levels in patients with DN were significantly higher than those in non-DN patients, suggesting that IGF-1 may be one of the pathogenesis of type 2 DM nephropathy .