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目的:探讨早卵泡期长效长方案的最佳获卵数及在达到较高累积活产率（cumulative live birth rate，CLBR）的同时，减少卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）的风险。方法:回顾性队列研究分析2014年1月至2017年12月期间在郑州大学第三附属医院生殖医学科首次行体外受精或卵胞质内单精子注射助孕且采用早卵泡期长效长方案的患者作为研究对象。根据获卵数进行分组，A组：获卵数1~5枚；B组：获卵数6~10枚；C组：获卵数11~15枚；D组：获卵数16~20枚；E组：获卵数>20枚，分析5组患者的基础资料及临床数据。主要观察指标为CLBR和OHSS发生率。采用二元逻辑回归校正混杂因素，分析影响CLBR和OHSS发生率的因素。结果:女方年龄的增加（an OR=0.93，95% n CI=0.90~0.97，n P20 oocytes. The basic and clinical data of 5 groups were analyzed. The main outcome measures were CLBR and the incidence of OHSS. Binary logistic regression was used to correct confounding factors to analyze the factors affecting the CLBR and the incidence of OHSS. We calculated the CLBR and the incidence of OHSS in each group.n Results:The maternal age (an OR=0.93, 95% n CI=0.90-0.97, n P<0.001) and body mass index (an OR=0.95, 95% n CI=0.92-0.99, n P=0.02) were risk factors for CLBR. The number of oocytes retrieved was the protection factor for CLBR (an OR=1.27, 95% n CI=1.20-1.35, n P<0.001). The maternal age (an OR=0.94, 95%n CI=0.91-0.97, n P<0.001), body mass index (an OR=0.96, 95% n CI=0.93-0.99, n P=0.04), and increase in the number of oocytes retrieved (an OR=1.84, 95% n CI=1.64-2.06, n P<0.001) were the independent risk factors of the incidence of OHSS. With the increase of the number of oocytes retrieved (group A to group C), CLBR increased significantly [51.6% (157/304), 64.8% (869/1314), 75.2% (1334/1774),n P0.05). With the increase in the number of oocytes retrieved (group A to group E), the incidence of OHSS increased significantly [0.3% (1/304), 3.3% (44/1314), 5.0% (88/1774), 9.8% (104/1065), 15.4% (77/499),n P15.n Conclusion:For the early follicular phase prolonged protocol, the optimal number of oocytes retrieved is 11-15, which can obtain higher CLBR, and reduce the incidence of OHSS.