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目的:探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)和血管生成与胃癌发展的关系.方法:应用免疫组织化学方法检测56例人胃癌组织碱性成纤维细胞生长因子表达和微血管密度(microvasculardensity,MVD),分析bFGF和MVD及其与胃癌组织学分型、浸润深度、生长方式、淋巴结转移、远处转移和预后的关系.结果:bFGF阳性者MVD值显著高于bFGF阴性者(P<0.01),MVD值和bFGF表达与胃癌浸润深度(P<0.05)、淋巴结转移(P<0.01)和远处转移(P<0.05)密切相关;MVD≥43或bFGF表达阳性的胃癌患者5年生存率较低.结论:血管生成在胃癌发展中具有重要作用,bFGF不仅与胃癌的血管生成有关,而且与胃癌的生长和浸润转移也有关,MVD或bFGF可作为判断胃癌患者预后的指标.
Objective: To investigate the relationship between basic fibroblast growth factor (bFGF) and angiogenesis and the development of gastric cancer. Methods: Immunohistochemistry was used to detect the expression of basic fibroblast growth factor and microvessels in 56 human gastric cancer tissues. Density (microvascular density, MVD) analysis of bFGF and MVD and their relationship with histological type, depth of invasion, growth pattern, lymph node metastasis, distant metastasis and prognosis of gastric cancer. Results: The MVD value of bFGF positive was significantly higher than that of bFGF negative ( P<0.01), MVD and bFGF expression were closely correlated with invasive depth (P<0.05), lymph node metastasis (P<0.01), and distant metastasis (P<0.05); gastric cancer patients with MVD≥43 or bFGF positive expression 5 The annual survival rate is low. Conclusion: Angiogenesis plays an important role in the development of gastric cancer. bFGF is not only related to angiogenesis in gastric cancer, but also related to the growth, invasion and metastasis of gastric cancer. MVD or bFGF may be used as an indicator to predict the prognosis of gastric cancer patients.