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目的观察阿奇霉素对支原体肺炎患儿相关炎症介质与免疫调节状态的影响,以了解阿奇霉素在支原体肺炎患儿中的应用价值。方法将2016年杭州市余杭区第一人民医院收治的202例支原体肺炎患儿根据随机分配的原则分为两组,对照组的101例患儿以红霉素进行治疗,观察组的101例患儿则以阿奇霉素进行治疗,检测与比较两组患儿不同时间点的相关炎症介质与免疫调节指标。结果治疗前对照组和观察组患儿相关炎症介质与免疫调节指标比较,差异均无统计学意义(P>0.05),治疗后3与7 d两组患儿的检测结果均持续改善,其中观察组的炎症介质与免疫调节指标表达均好于对照组同时间点的检测结果,差异均有统计学意义(P<0.05)。结论阿奇霉素对支原体肺炎患儿相关炎症介质与免疫调节状态的影响相对更好,为患儿的康复奠定了基础,因此临床应用价值更高。
Objective To observe the effects of azithromycin on the inflammatory mediators and immunoregulatory status in children with mycoplasma pneumonia and to find out the value of azithromycin in children with mycoplasma pneumonia. Methods Totally 202 children with mycoplasma pneumonia admitted from the First People’s Hospital of Yuhang District in Hangzhou in 2016 were divided into two groups according to the principle of random distribution. One hundred and ten children in the control group were treated with erythromycin. One hundred and eleven patients in the observation group Children were treated with azithromycin to detect and compare the two groups of children at different time points related to inflammatory mediators and immune regulation. Results There was no significant difference in inflammatory mediators and immunoregulation between control group and observation group before treatment (P> 0.05). After 3 and 7 days of treatment, the detection results of both groups continued to improve, of which observation The expression of inflammatory mediators and immunoregulation indicators in the group were better than those in the control group at the same time point, the difference was statistically significant (P <0.05). Conclusion Azithromycin has a relatively better effect on the related inflammatory mediators and immunoregulatory status in children with mycoplasma pneumonia, which lays the foundation for the rehabilitation of children, so the value of clinical application is higher.