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目的:研究并探讨神经节苷脂联合早期干预治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法:于2012年1月至2015年10月,在本院新生儿科病房中,随机抽取100例HIE患者分为对照组和观察组(各50例),对照组患者实施常规治疗,观察组在此基础上实施神经节苷脂和早期干预治疗。比较两组患者的临床总有效率、体征恢复时间以及NBNA评分。结果:与对照组相比,观察组的临床总有效率明显升高(96%vs 80%,P<0.05),意识恢复时间、肌张力恢复时间以及原始反射恢复时间均明显缩短(P<0.05)。治疗后对照组和观察组的NBNA评分均明显提高(均P<0.05),观察组改善水平优对照组(P<0.05)。结论:在HIE的临床治疗中加用神经节苷脂,并实施早期干预,具有较好的临床疗效。
Objective: To study and explore the clinical efficacy of ganglioside combined with early intervention in neonatal hypoxic-ischemic encephalopathy (HIE). Methods: From January 2012 to October 2015, 100 HIE patients were randomly divided into control group and observation group (50 cases each) in the neonatal ward of our hospital. Patients in the control group were treated with conventional therapy. This is based on the administration of gangliosides and early intervention. The total clinical efficacy, recovery time and NBNA score were compared between the two groups. Results: Compared with the control group, the total effective rate in the observation group was significantly increased (96% vs 80%, P <0.05), and the recovery time of consciousness, recovery time of muscle tone and recovery time of original reflex were significantly shorter (P <0.05 ). After treatment, the NBNA scores of the control group and the observation group were significantly increased (all P <0.05), and the improvement of the observation group was better than that of the control group (P <0.05). Conclusion: Ganglioside is added in the clinical treatment of HIE and early intervention is performed, which has good clinical efficacy.