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目的观察甲硝唑联合克林霉素治疗细菌性阴道炎患者的临床效果和安全性。方法将186例细菌性阴道炎患者随机分为对照组和观察组,每组93例。对照组单独给予甲硝唑治疗,观察组在甲硝唑治疗基础上联合克林霉素治疗,观察2组临床治疗效果及患者疾病复发情况。结果观察组总有效率为96.8%,高于对照组的78.5%(P<0.05)。观察组复发率为9.7%,低于对照组的32.3%(P<0.05)。结论甲硝唑联合克林霉素治疗细菌性阴道炎临床效果显著,安全性好,值得临床推广应用。
Objective To observe the clinical effect and safety of metronidazole combined with clindamycin in the treatment of bacterial vaginosis. Methods 186 cases of bacterial vaginosis were randomly divided into control group and observation group, 93 cases in each group. The control group was treated with metronidazole alone. The observation group was treated with clindamycin on the basis of metronidazole treatment. The clinical effects and recurrence of the disease were observed in the two groups. Results The total effective rate in observation group was 96.8%, which was higher than 78.5% in control group (P <0.05). The recurrence rate in observation group was 9.7%, which was lower than that in control group (32.3%, P <0.05). Conclusion The clinical effect of metronidazole combined with clindamycin in the treatment of bacterial vaginosis is significant, safe and worthy of clinical application.