由于IL-12家族在免疫调节中发挥着重要的作用,因此日益受到科研工作者的重视。目前已知IL-12家族主要包括4个成员,分别是IL-12、IL-23、IL-27及IL-35。该家族细胞因子是由结构相似、共价结合的异源二聚体分子组成,也是目前已知在众多的细胞因子家族中唯一的异源二聚体细胞因子家族。IL-12家族细胞因子虽然共享着许多 As IL-12 family plays an important role in immune regulation, it is paid more and more attention by researchers. It is currently known that the IL-12 family mainly includes four members, namely, IL-12, IL-23, IL-27 and IL-35. This family of cytokines is composed of structurally similar, covalently bound heterodimeric molecules and is also the only family of heterodimeric cytokines known to date among a number of cytokine families. Although IL-12 family cytokines share many