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目的为了提高出生人口的素质,对有产前诊断指征的3 484例孕中期孕妇羊水细胞染色体核型分析,了解异常核型与产前诊断指标的关系。方法对3 484例有产前诊断指征的孕妇,在B超定位下进行羊膜腔穿刺术,抽取孕妇羊水20 ml进行细胞培养、染色体制备、染色体核型分析。结果发现异常核型126例,异常核型发生率为3.62%(126/3 484),其中染色体数目异常87例,占69.05%;染色体结构异常31例,占24.60%;既有染色体数目异常又有结构异常的8例,占6.35%。结论对有产前诊断指征的孕妇做羊水细胞染色体核型分析,是诊断胎儿染色体病准确、安全、可靠的方法。
Objective To improve the quality of the born population, we analyzed the karyotypes of 3 484 pregnant women with prenatal diagnosis of pregnant women with amniotic fluid cells in order to understand the relationship between abnormal karyotype and prenatal diagnosis. Methods A total of 3 484 pregnant women with prenatal diagnosis were enrolled in this study. Amniocentesis was performed under B-mode ultrasonography. Twenty ml of pregnant women’s amniotic fluid were drawn for cell culture, chromosome preparation and chromosome karyotype analysis. The results showed that there were 126 cases of abnormal karyotype, the incidence of abnormal karyotype was 3.62% (126/3 484), of which 87 cases were abnormal (accounting for 69.05%), 31 cases were chromosomal abnormalities (24.60%), both chromosomal abnormalities There are 8 cases of structural abnormalities, accounting for 6.35%. Conclusions It is an accurate, safe and reliable method to diagnose fetal chromosomal diseases by analyzing the karyotypes of amniotic fluid cells in pregnant women with prenatal diagnosis indications.