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目的测定SPF级和普通级Hartley豚鼠的主要脏器质量,比较屏障环境和普通环境下豚鼠脏器系数的差异。方法取2月龄SPF级和普通级豚鼠雌雄各30只,剖检取心、肝、脾、肺、肾等13个脏器,称其质量并计算脏器系数。结果 SPF级和普通级Hartley豚鼠雌性之间比较,体质量、心、脾、肺、肾、肾上腺、子宫质量差异极显著(P<0.01);SPF级和普通级Hartley豚鼠雄性之间比较,心、肝、脾、肺、肾、肾上腺、胸腺、睾丸、附睾等其质量差异极显著(P<0.01)。SPF级和普通级Hartley豚鼠雌性之间比较,心、脾、肺、肾、肾上腺、子宫的脏器系数差异极显著(P<0.01)。SPF级和普通级Hartley豚鼠雄性之间比较,心、肝、脾、肺、肾、肾上腺、胸腺、睾丸、附睾的脏器系数差异极显著(P<0.01)。结论 SPF级和普通级Hartley豚鼠比,除脑以外的脏器系数均有显著差异,且普通级豚鼠的脏器系数普遍高于SPF级豚鼠。
OBJECTIVE: To determine the quality of major organ in SPF and normal Hartley guinea pigs, and to compare the difference between the barrier environment and the organ coefficient in guinea pig under normal conditions. Methods Thirty male and female SPF and normal guinea pigs at 2 months old were randomly divided into three groups: heart, liver, spleen, lung, kidney and other organs. The quality of the organ was calculated and the organ coefficient was calculated. Results There were significant differences in body weight, heart, spleen, lung, kidney, adrenal gland and uterus between SPF and Hartley guinea pigs (P <0.01). Compared with male Hartley guinea pigs, , Liver, spleen, lung, kidney, adrenal, thymus, testis and epididymis were significantly different (P <0.01). The differences of organ coefficients of heart, spleen, lung, kidney, adrenal and uterus between SPF and normal Hartley guinea pigs were significant (P <0.01). The differences in organ coefficient of heart, liver, spleen, lung, kidney, adrenal gland, thymus, testis and epididymis between SPF and normal Hartley guinea pigs were significant (P <0.01). CONCLUSIONS: There are significant differences in the organ coefficient except for brain except for SPF and normal Hartley guinea pigs, and the organ coefficient of ordinary guinea pigs is generally higher than that of SPF guinea pigs.