【摘 要】
：
目的:研究黄芪皂苷Ⅱ(Astragaloside-Ⅱ,AS-Ⅱ)对链脲佐菌素(Streptozocin,STZ)诱导的糖尿病肾病(Diabetic nephrology,DN)大鼠肾脏的保护作用.方法:将8周龄雄性SD(Sprague-D
【机 构】
：
上海交通大学附属第六人民医院肾内科上海 200233;上海交通大学附属第六人民医院肾内科 上海 200233;上海健康医学院附属第六人民医院东院肾脏风湿科 上海 201306;上海海洋大学 上海 20
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目的:研究黄芪皂苷Ⅱ(Astragaloside-Ⅱ,AS-Ⅱ)对链脲佐菌素(Streptozocin,STZ)诱导的糖尿病肾病(Diabetic nephrology,DN)大鼠肾脏的保护作用.方法:将8周龄雄性SD(Sprague-Dawley)大鼠随机选取5只作为正常对照组,其余大鼠予腹腔注射55 mg/kg剂量STZ建立糖尿病模型.造模成功的大鼠随机分为模型组与AS-Ⅱ治疗组,每组5只.AS-Ⅱ治疗组予AS-Ⅱ 3.2mg/(kgod)连续口服灌胃治疗9周,同时正常对照组和模型组给予等量生理盐水溶液灌胃.第9周末,收集大鼠24 h尿液测定尿微量白蛋白浓度,留取肾脏组织观察肾脏病理改变并检测肾组织中足细胞裂孔隔膜蛋白Nephrin、WT1和caspase-3的表达.结果:与糖尿病模型组比较,AS-Ⅱ治疗组DN大鼠肾脏病理损伤明显改善,caspase-3表达明显减少,Nephrin和WT1表达增加,尿蛋白排泄减轻(P＜0.05).结论:AS-Ⅱ治疗可改善DN大鼠肾脏足细胞凋亡,降低尿蛋白,具有肾脏保护作用.
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