TA 1和TA 2系小鼠已被我国卫生部定为国际通用实验动物,在国内已广泛使用。低癌系TA 1和高癌系TA 2小鼠的生物学特性业已报道,但该两系小鼠自发性乳腺肿瘤病理组织学分型及转移的资料还是空白。为了便于同国外同类资料进行比较,和提供必要数据,我们对1977年以来所积累的两系小鼠自发乳癌的尸检材料进行病理组织学分型及转移病例的分析。 TA 1 and TA 2 mice have been designated as international laboratory animals by the Ministry of Health of China and have been widely used in China. The biological characteristics of low-grade TA 1 and high-grade TA 2 mice have been reported, but the histological types and metastasis of spontaneous breast tumors in the two-line mice are still blank. In order to facilitate comparison with similar foreign data and provide necessary data, we analyzed the histopathological type and metastatic cases of the autopsy materials of spontaneous breast cancer of two-line mice that had been accumulated since 1977.