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与抗生素治疗有关的出血性疾病可以很严重。Ham首次报道注射氨苄青霉素(1例加用卡那霉素)治疗的5例患者,发生了凝血酶原减少症(其中2例出血需要输血,2例少量出血),用维生素K后凝血酶原时间恢复正常,出血停止。Pineo等报告15例患者,术后发生维生素K缺乏(凝血酶原时间延长),9例有胃肠道出血,其中8例接受过广谱抗生素治疗和静脉输液。这种凝血酶原减少症被认为是由于口服维生素K不足和肠道微生物被抗生素抑制致使维生素K内源性生成减少所致。在58例注射Cephamandole(在胆汁中浓度高)及静脉输注营养物的患者中,10例表现了类似现象。因此,对这类患者应常规地检测凝血酶原
Hemorrhagic diseases associated with antibiotic treatment can be severe. Ham first reported 5 cases of ampicillin injection (1 plus kanamycin) treatment of patients with prothrombin reduction occurred (of which 2 cases of bleeding need blood transfusion, 2 cases of a small amount of bleeding), with vitamin K after prothrombin Time returned to normal, bleeding stopped. Pineo et al reported 15 patients with postoperative vitamin K deficiency (prolonged prothrombin time) and 9 with gastrointestinal bleeding, 8 of whom received broad-spectrum antibiotic therapy and intravenous fluids. This prothrombin reduction is thought to be due to a decrease in endogenous production of vitamin K due to inadequate oral vitamin K and intestinal microbial suppression by antibiotics. Of 58 patients who received Cephamandole (high in bile) and intravenous infusions, 10 showed similar behavior. Therefore, such patients should routinely detect prothrombin