治疗药监测(therapeutic drug monitoring,简称TDM),是新兴边缘学科—药物代谢动力学(pharmacokinetics,简称药代动力学)的临床应用部分.通过监测药物在血浆中的浓度达到用药个体化的目的.TDM 在我国儿科临床的应用只有短短数年时间,现将初步体会总结如下.下列情况需要进行血药浓度监测(1)血药浓度与疗效和毒性反应关系密切;(2)有效血药浓度范围窄,低浓度疗效不佳,高浓度有引致毒性反应的危险;(3)已有被公认的有效血药浓度范围 Therapeutic drug monitoring (referred to as TDM) is a new emerging edge discipline - pharmacokinetics (pharmacokinetics) clinical application of part of the drug by monitoring the concentration in the plasma to achieve the purpose of drug use. TDM pediatric clinical application in China only a few short years, the initial experience is summarized as follows. The following conditions need to monitor blood concentration (1) blood concentration and efficacy and toxicity are closely related; (2) the effective plasma concentration Narrow range, poor efficacy of low concentrations, high concentrations have the risk of causing toxic reactions; (3) has been recognized as effective plasma concentration range