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目的对疣状表皮发育不良患者皮损的共聚焦激光扫描显微镜(CLSM)图像特征进行初步探索。方法对在我院就诊高度怀疑为疣状表皮发育不良的患者,选定皮损处先做共聚焦激光扫描显微镜扫描,再在该处行组织病理检查,并在皮损附近正常皮肤处做CLSM检查,用做皮损对照。同时选取临床诊断为扁平疣的20例患者与之对照。结果皮损处CLSM图像可见明亮的角质层增厚,表皮中上部较多体积大,形状不规则,大小不一,胞质低折光率呈现黑色的空泡细胞,真皮浅层血管周围可见少量高折光度的淋巴细胞。对照组扁平疣患者CLSM扫描图像:其空泡细胞大小较为一致,呈圆形、椭圆形或梭形,胞质折光率较低。结论疣状表皮发育不良的CLSM图像有一定的特征性,但由于例数有限,其特征有待于进一步发现和证实,此外它能监测该病的动态变化。但应注意与易混淆的CLSM图像相鉴别。
Objective To explore the CLSM images of lesions in patients with verrucous epidermal dysplasia. Methods In our hospital a high degree of suspicion of patients with verrucous epidermal dysplasia, the selected lesion at first do confocal laser scanning microscopy, then the Department of pathological examination, and in the normal skin near the lesion CLSM Check, used as a lesion control. At the same time, 20 patients with flat warts were selected as controls. Results CLSM image showed a bright cuticle thickening, the upper epidermis more bulky, irregular shape, size, low refractive index of the cytoplasm showing black vacuolar cells, a small amount of visible around the superficial dermal layer of blood vessels Refractive degree of lymphocytes. CLSM scan images of the control group of flat warts: its vacuolar cells are more consistent, round, oval or fusiform, low refractive index of the cytoplasm. Conclusions CLSM images of verrucous epidermal dysplasia have certain characteristics. However, due to the limited number of cases, their characteristics need to be further found and confirmed. In addition, it can monitor the dynamic changes of the disease. However, care should be taken to distinguish it from confusing CLSM images.