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目的 :研究iNOS与NF κB在胃癌中的表达 ,探讨两者与胃癌发生、发展之间的关系及意义。方法 :采用免疫组化法对5 3例胃癌组织和 2 0例正常胃黏膜组织标本进行检测 ,观察iNOS和NF κB的表达情况。结果 :iNOS及NF κB在胃癌组织中均呈高表达状态 (71 70 %、83 0 2 % ) ,其阳性表达率明显高于正常胃黏膜组织 ,差异有显著性 (P <0 0 5 )。同时 ,iNOS和NF κB在胃癌中的高表达与组织学分型无关 (P >0 0 5 ) ,而与浸润深度和有无淋巴结转移有关 (P <0 0 5 ) ,且两者之间存在显著相关性 (r =0 .60 8,P <0 0 1)。结论 :iNOS及NF κB参与了肿瘤的形成 ,且与胃癌的侵袭、转移及预后也有一定关系
Objective: To study the expression of iNOS and NF-κB in gastric cancer and to explore the relationship between them and the occurrence and development of gastric cancer. Methods: Fifty-three gastric cancer tissues and 20 normal gastric mucosa specimens were examined by immunohistochemistry to observe the expression of iNOS and NF-κB. Results: The expressions of iNOS and NF-κB in gastric cancer tissues were highly expressed (71 70%, 83 0 2%). The positive rates of iNOS and NF κB in gastric cancer tissues were significantly higher than those in normal gastric mucosa (P <0.05). Meanwhile, the overexpression of iNOS and NF-κB in gastric cancer was not related to the histological type (P> 0.05), but related to the depth of invasion and lymph node metastasis (P <0.05), and there was significant difference between them Correlation (r = 0.60 8, P <0 0 1). Conclusions: iNOS and NF-κB are involved in the formation of tumors and have some relations with invasion, metastasis and prognosis of gastric cancer