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目的：观察地尔硫艹卓对冠心病患者经皮冠状动脉介入治疗（PCI）效果的影响。方法选择行PCI 术治疗的冠心病患者116例，按随机数字表法分为观察组62例和对照组54例，对照组给予常规治疗，观察组在对照组基础上加用地尔硫艹卓治疗。记录两组术前、术后24 h、术后48 h 的 BP、HR、氨基末端脑钠肽前体（NT-proBNP）、CRP 水平变化以及治疗前后心绞痛发生次数。术后随访6个月，记录该时间段内患者主要不良心血管事件的发生情况。结果观察组、对照组术后即刻 CRP 水平分别为（40．1±7．4）mg／L、（41．7±8．8）mg／L，NT-proBNP 水平分别为（501．8±56．5）ng／L、（445．7±50．6）ng／L，两者较术前均明显升高（t ＝5．684，P ＜0．05）。术后24 h 观察组舒张压、收缩压、心率、CRP、NT-proBNP 分别为（73．1±6．2）mmHg、（121．7±15．8）mmHg、（68．1±7．9）次／min、（24．8±3．7）mg／L、（201．7±20．6）ng／L，与对照组的（85．6±9．3）mmHg、（134．3±17．4）mmHg、（77．5±9．2）次／min、（36．5±7．9）mg／L、（481．5±48．2）ng／L 相比，均有明显降低，且一直保持到术后48 h（F ＝7．281、8．097、6．945、7．682、6．517，均 P ＜0．05）；治疗后观察组与对照组心绞痛发生次数分别为（1．5±0．9）次／月、（2．9±0．7）次／月均比治疗前的（8．3±2．6）次／月、（8．2±2．4）次／月有所减少，观察组比对照组减少程度更加显著（t ＝7．584，P ＜0．05）；观察组主要不良心血管事件的总发生率为4．84％，与对照组的9．26％相比明显降低（χ2＝6．942，P ＜0．05）。结论 PCI 术后给予地尔硫艹卓，可降低患者的不良反应，有助于改善患者的预后。“,”Objective To observe the clinical efficacy of diltiazem in patients with coronary disease following percutaneous coronary intervention(PCI).Methods From Jan 2014 to Jan 2016,116 cases of coronary disease were selected as the research subjects,they were randomly divided into the observation group(62cases)and the control group(54 cases).The control group was given conventional therapy,while the observation group was given diltiazem therapy on the basis of control group.The levels of BP,HR,NT -proBNP,CRP and angina frequency in the two groups were compared before and 24h,48h after PCI.The incidence of major adverse cardiovascular events(MACEs) was assessed at the sixth month after PCI.Results After surgery,the CRP levels of the observation group and control group were (40.1 ±7.4)mg/L and (41.7 ±8.8)mg/L,the NT -proBNP levels of the two groups were (501.8 ± 56.5)ng/L and (445.7 ±50.6)ng/L,which were significantly higher than preoperation(t =5.684,P <0.05).The blood pressure,heart rate,CRP,NT -proBNP of the observation group since 24 hours after PCI were (73.1 ± 6.2)mmHg,(121.7 ±15.8)mmHg,(68.1 ±7.9)times/min,(24.8 ±3.7)mg/L,(201.7 ±20.6)ng/L,which were significantly lower than those of control group [(85.6 ±9.3 )mmHg,(134.3 ±17.4)mmHg,(77.5 ± 9.2)times/min,(36.5 ±7.9)mg/L,(481.5 ±48.2)ng/L].The effect was kept over 48 hours(F =7.281,8.097, 6.945,7.682,6.517,all P <0.05).Angina pectoris after treatment in the observation group and control group were (1.5 ±0.9)times/month,(2.9 ±0.7)times/month,which were significantly lower than before treatment(t =7.584,P <0.05).The incidence rate of total MACE in the observation group was 4.84%,which was significantly lower than that in the control group(χ2 =6.942,P <0.05).Conclusion Diltiazem after PCI can decrease the adverse reaction, and help to improve the prognosis of patients.