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目的:观察二甲双胍对中老年高血压前期代谢综合征患者的疗效。方法:将480例中老年高血压前期人群中代谢综合征患者随机分为两组各240例,均干预生活方式,治疗组加用二甲双胍。结果:对照组治疗3个月后体重指数、收缩压、舒张压、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、餐后2 h血糖、丙氨酸氨基转移酶、C反应蛋白、胰岛素抵抗指数、颈动脉内膜-中层厚度等指标均较治疗前改善(P<0.05),治疗组干预3个月后上述指标较治疗前改善更明显(P<0.05),与对照组比较差异有统计学意义(P<0.01)。结论:在干预生活方式的基础上给予二甲双胍,或可作为中老年高血压前期人群中代谢综合征患者的药物治疗手段。
Objective: To observe the effect of metformin on the elderly with metabolic syndrome in the elderly. Methods: A total of 480 patients with metabolic syndrome in pre-hypertensive population of 480 middle-aged and elderly patients were randomly divided into two groups of 240 patients, all of whom were given lifestyle intervention. Metformin was added to the treatment group. Results: Body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, high density lipoprotein cholesterol, fasting blood glucose, 2 h postprandial blood glucose, alanine aminotransferase, C-reactive protein and insulin resistance Index and carotid artery intima-media thickness (P <0.05). Compared with those before treatment, the above indexes in the treatment group improved more obviously than those before treatment (P <0.05), and the difference was statistically significant compared with the control group Significance (P <0.01). CONCLUSIONS: Metformin is given on the basis of lifestyle interventions or can be used as a medication for patients with metabolic syndrome in pre-hypertensive population.