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目的:探讨分析米非司酮及米索前列醇流产的安全性。方法:采用循证医学的方法,对检索医学数据库和10种中文期刊,遴选有关药物流产安全性研究的文献,进行系统分析评估。结果:共选择文献98篇,药物流产1 260例,其中药物严重不良反应105例(8.30%),一般不良反应1 155例(91.67%)。结论:药物流产的严重不良反应率较低,对药物流产应用影响甚微,但应规范药物流产不良反应监测程序及措施,减少产后出血仍是目前及今后继续研究的方向。
Objective: To investigate the safety of mifepristone and misoprostol abortion. Methods: Evidence-based medicine was used to search the medical database and 10 kinds of Chinese journals, and to select the literature on the safety of medical abortion. Results: A total of 98 articles were selected and 1 260 cases of medical abortion were observed. Among them, 105 (8.30%) were serious adverse drug reactions and 1 155 (91.67%) were general adverse reactions. Conclusion: The low rate of serious adverse reactions caused by medical abortion has little effect on the application of medical abortion. However, the monitoring procedures and measures of abortion adverse reactions should be standardized to reduce the postpartum hemorrhage and it is still the research direction now and in the future.